Researchers from University of Seville assessed the feasibility of ultrasound assisted compression in producing sustained release matrix tablets based on elastic thermoplastic polyurethanes
Tablets are widely used as form of dosage in treatment of various diseases. Development of generic drugs has further led to high adoption of tablets. To achieve the targeted properties of the finished drug product and to obtain suitable properties for industrial processing, either wet or dry granulation has to precede the compaction step. Ultrasound-assisted compression (USAC) is a technology that integrates a conventional compression process and ultrasound irradiation. Ultrasound energy can be used to heat and sinter materials.
Now, to obtain tablets by direct compression, a team of researchers from University of Seville assessed the feasibility of USAC in addressing the adverse elastic properties of thermoplastic polymer. The team also studied the properties of the obtained tablets. TecoflexTM EG-72D – an elastic thermoplastic polyurethane (TPU) was used as the matrix that forms excipient in tablets obtained by USAC. The team also assessed the major properties of the obtained high drug content TPU matrices. The team used Anhydrous theophylline – a medication that belongs to a class of drugs known as xanthines – as model drug and tablets of TPU and theophylline were successfully obtained by USAC for all batches. The drug release data was assessed according to different kinetic models: Higuchi, Korsmeyer and Peppas and Sahlin.
The sintering process of elastic TPU particles offered inert matrices with a semi-continuum excipient structure. According to the researchers, the approach can be used to produce low quantity polymer matrices that have high excipient efficiency. The analysis of fractal nature that was revealed in the pore structure aided in comprehending the behavior of TPU matrices in drug delivery. The results confirmed the efficiency of USAC matrices among a wide range of drug particle size fractions. Although USAC is considered as an efficient approach in compressing elastic materials, according to the researchers, the current study is a pioneering example in which the approach was used to compress an elastic thermoplastic polymer. The research was published in the journal MDPI Pharmaceuticals on April 2, 2019.
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