Bone Glue: Cementing the Path to Effective Bone Healing

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Osteoporosis is a common cause for bone fractures and its prevalence gradually increases with age. For instance, the prevalence ratio of osteoporosis increase from 5% at 50 years to 50% at 85 years among women. According to the National Osteoporosis Foundation, there were 7-8 million females aged over 50 years suffering from osteoporosis and 21.8 million suffering from osteopenia in the U.S., in 2002. It further states that the number of bone fractures will increase by 2 to 4 times by 2020 and 41 million women will suffering from osteoporosis or osteopenia. This is mainly attributed to significant rise in the aging population. In 2002, 12–17% of the population in Europe were aged over 65, which is expected to increase to 20–25% by 2025. As bone health significantly deteriorates with age, this would lead to a large number of falls and resultant fractures. Statistics released by the National Osteoporosis Foundation further revealed that 1.3 million hip fractures were report worldwide in 1990, which is expected to increase by 4.5 million by 2050. This inadvertently will boost growth of the bone glue market. According to Medanta Medicity—a major multi-specialty hospital based in India—Indians are found to have 15% lower bone density which puts Indians at a greater risk of broken bones compared to Caucasians.

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The global bone glue market was valued at US$ 1,648.3 million in 2015 and is expected to witness a CAGR of 6.3% during the forecast period (2016 – 2024).

Figure 1. Global Bone Glue Market Share, By Product Type (%)

Bone Glue Market

Naturally produced bone glue from animals hits the bone glue market

The growing prevalence of bone disorders and ageing population are the important aspects for the significant growth in bone glue market in Europe. Growing number of arthroplasty procedures and the consequent rise in demand for newer bone glues across various countries in Europe would further fuel growth of bone glue market in the region. However, stringent regulations in US such as, institutions and universities who use animals for research purpose should be licensed and or registered with the U.S. Department of Agriculture and facilities, regulated animals must be inspected yearly by USDA’s Animal and Plant Health Inspection Service, has hit the bone glue market by inhibiting the production of natural glue obtained from animals. Non-animal substitutes i.e. synthetic glue are relatively more expensive and can also lead to compatibility issues. Difficulties such as the irritation caused by the cement to the surrounding skin, over prolong application, breakdown of the cement can cause the artificial joint to come loose, breakage of cement in bits are associated with cemented arthroplasty is the one of the main concerns which hamper the growth of the bone glue market.

Bone cement implantation syndrome is most prominent in patients undergoing hip fracture treatment

Bone glue is a basic product needed in any minor fractures and also act as beneficial supplements for musculoskeletal tissue suture repair. There are various other options such as bone cement and bone surgery to treat multiple fractures. A study was conducted by various medical institutes and university hospitals in 2014, with a patient pool of around 1,016 patients who underwent cemented hemiarthroplasty at some point in their life. A common symptom called bone cement implantation syndrome was observed in people suffering from hip fractures and the incidence rate was reported to be between 25% and 30%. Severe bone cement implantation syndrome was observed in 5–7% of patients in the study group. Independent preoperative threat issues for occurrence of bone cement implantation syndrome were irregularities in overall health conducted by the universities, i.e. ASA scores, COPD, and medication with diuretics and warfarin. In cemented total hip arthroplasty, fatalities were pegged at 0.11% and the death occurred during the time of cementation. Considering all these factors, companies have developed bone glue products. The increased usage of bone glue in such cases would boost growth of the bone glue market.

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