Increased Consumption of Coffee Decreases the Level of Endocannabinoid System

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Level of endocannabinoid system in human body decreases in people who consume five to eight cups of coffee a day, according to a report published on March 15, 2018.

Endocannabinoids are neurotransmitters that are bound to cannabinoid receptors and these molecules are produced in the human body. Endocannabinoid chemicals, which are boosted by smoking marijuana are suppressed by coffee. Apart from endocannabinoids, coffee alters 115 other metabolites present in the blood and few of these metabolites are required for biological processes in human body.

Marilyn Cornelis, an assistant professor of preventative medicine and her team analyzed five biological processes out of which two were expected, which includes xanthine metabolism and benzoate metabolism. Caffeine metabolism process happens in xanthine metabolism and polyphenols present in coffee, with the help of gut bacteria, are broken down in benzoate metabolism. Researchers observed that the impacts caused by coffee and cannabis on the systems were overlapping. These molecules, which decreases with an increase in consumption of coffee, also decreases when the body is under stress. Concentration of steroid metabolites was also found to increase with coffee consumption.

Cornelis said, “The goal of my research is to understand the causal reasons that link coffee to those outcomes.” They conducted this study based on a clinical trial that was conducted in Finland. 47 coffee drinkers who were asked to drink medium-roast arabica blend were observed during the study. The participant’s blood samples were collected to test 733 metabolites. She said, “It would be interesting to see if there were some genetic differences in the response to coffee as well.”


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