Modulation of Fgf21 Gene Improves Diet-Induced Obesity

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Research reveals that diet-induced obesity in adulthood can be improved by the modulation of Fgf21 gene, according to a study conducted on March 9, 2018.

Good nutrition is an important factor in the early development of children. Body weight during adulthood is the effect of nutritional experiences in early life. For instance, a child who is malnourished in early life has increased chances of suffering from metabolic diseases such as obesity in later life.

Previously, a team of researchers had found that the onset of lactation after birth leads to the activation of nuclear receptor peroxisome proliferator-activated receptor (PPAR)α, which are caused by the milk lipids that serve as a ligand. This receptor plays a major role in transcriptional regulation of liver fat metabolism. They also found that addition of a synthetic PPARα ligand to mouse dams during the perinatal period reduced DNA methylation of fatty-acid β-oxidation genes in the offspring’s liver. An epigenetic mechanism used by cells to control gene expression is known as DNA methylation. These results led to the current study of exploring if DNA methylation status of PPARα target genes, which is modulated in early life, persists in adulthood.

Koshi Hashimoto, a corresponding author said, “In the current study, using a genome-wide analysis of DNA methylation, we identified a few PPARα target genes that underwent ligand-activated PPARα-dependent DNA demethylation during the perinatal period and whose DNA methylation status persists into adulthood.” This is the first detailed analysis of DNA methylation status of a particular gene throughout life.

This study can be related to the weight loss and weight management market, as detailed in the weight loss and weight management market report published by Coherent Market Insights.


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