Researchers reveal that small bacterial infections such as mild food poisoning can lead to chronic inflammation and life-threatening colitis, according to a study conducted on December 21, 2017.
Some bacterial infections such as mild food poisoning, which can be easily cleared by the body without any treatment are found to start a chain of events leading to chronic inflammation and colitis. With the help of this study, origins of inflammatory bowel disease (IBD) may be identified. It took eight years for the researchers to make this breakthrough. Through a different hypothesis, the study to find the origin of chronic inflammatory diseases was initiated by the researchers.
Many results were obtained from their hypothesis. It was found that genetic makeup does not have much role in the onset of chronic diseases. Reports obtained from other laboratories showed relation between seasonal bacterial infections in humans and increased diagnoses if IBD.
Using a healthy mice, a model of mild human food poisoning was developed by the researchers. Low dose of a bacterial pathogen, known as Salmonella Typhimurium was administered into the mice. Intestinal discomfort and dysfunction are the results mostly obtained. There was an increase observed in the inflammation by the fourth injection.
The reason for this was the deficiency of an enzyme called as intestinal alkaline phosphatase (IAP). When the neuraminidase activity was elevated by the salmonella infection, IAP deficiency was observed in the colon. Phosphates from molecules such as pro-inflammatory lipopolysaccharide (LPS) is removed by IAP. Methods to boost IAP levels and slow down the activity of neuraminidase does exist.
These infections in humans can be reduced to a large extent by preventing food contamination. Therefore, by developing new methods for food safety testing, an increase in the growth of global food safety testing market can be observed, as elaborated in the global food safety testing market report published by Coherent Market Insights,